Coffy is a nurse whose younger sister gets involved in drugs and is severely injured by contaminated heroin. Coffy sets out on a mission of vengeance and vigilante justice, killing drug dealers, pimps, and mobsters who cross her path. Pam Grier's first leading role is Coffy, a dedicated nurse who is fed up with the narcotics that have infiltrated the inner city. When her eleven-year-old sister is hospitalized after shooting some contaminated heroin, Coffy hits the streets with a loaded shotgun, determined to stop the drug trade once and for all.